chiron

BMF 85-Biogenic Amines

商品說明

Biogenic Amines

BMF 85 – Biogenic Amines

A biogenic amine is a naturally produced substance containing one or more amine group. There are five established biogenic amine neurotransmitters: the three catecholamines – dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline) plus histamine and serotonin. Catecholamines are released into the bloodstream in response to physical or emotional stress. These are known as the ‘flight or fight’ hormones and are responsible in part for that ‘rush’ people feel when they are afraid. Catecholamines are produced by chromaffin cells in the medulla of the adrenal gland.

Phaeochromocytoma (PCC)

Catecholamines are of clinical interest because they are diagnostic of phaeochromocytoma (PCC), a tumour of the chromaffin cells. Approximately 15% of tumours occur outside the adrenal glands (typically in the abdomen) and are called paragangliomas. Tumours may grow very large, but most are less than 10 cm. Approximately 10% are cancerous.

PCC is more common in women than in men. It occurs in early to mid-adulthood. 10% occur in children. PCC can be hereditary (Multiple Endocrine Neoplasia (MEN), Von Hippel-Lindau Syndrome, Neurofibromatosis) but may also develop sporadically.

The signs and symptoms are a consequence of over activity of the sympathetic nervous system:

Signs and symptoms of PCC

Headaches

Tremors

Sweating

Weakness

Fast heart beat

Abdominal pain

High blood pressure

Weight loss

• Anxiety or panic attacks

Elevated blood glucose

Nausea

Sudden death

Not all patients experience all of these signs and symptoms. The most common presentation is headache, sweating and increased heart rate. Symptoms occur in discrete attacks at unpredictable intervals, and usually last 15 to 20 minutes.

A doctor is more likely to consider PCC if the patient is young and has no other risk factors or habits that may cause these findings. Some people never develop symptoms. Up to 10% of cases are discovered incidentally.

www.chiron.no | E-mail: sales@chiron.no | Tel.: +47 73 87 44 90 | Fax.: +47 73 73 87 44 99 | BMF 85 p.1/4, 12_16

BMF 85 – Biogenic Amines

Diagnosis

Familial history > Genetic testing

24 Hour urine test

Plasma catecholamines

Imaging

Biopsy

If a tumour is intermittently secreting catecholamines plasma tests may fail to detect any abnormality, whereas urine measurements are more likely to be elevated. Urine and plasma metanephrines (catecholamine metabolites) may be preferred as they are usually present in greater quantities than catecholamines in the urine, and can persist in the blood even when catecholamine levels have returned to normal.

Treatment

Surgery is the definitive treatment for PCC. Where tumours are confined to the adrenal gland and are benign there is a good prognosis. Recurrence rates average around 10%. Patients with recurrent tumours, tumours that spread or unable to be removed surgically, have a fair to poor outlook. Other treatments include alpha blockers to control blood pressure, tyrosine kinase inhibitors to inhibit the formation of hormones by the tumour or chemo therapy / radio therapy for malignant tumours.

Other applications

Biogenic amines may also be used for diagnosis of neuroblastoma, the most common cancer in infancy, or carcinoid tumour, a slow-growing type of neuroendocrine tumour.

www.chiron.no | E-mail: sales@chiron.no | Tel.: +47 73 87 44 90 | Fax.: +47 73 73 87 44 99 | BMF 85 p.2/4, 12_16

BMF 85 – Biogenic Amines

Chiron now offer standards and standard mixes for catecholamines:

Catalogue No.

Description

Cas No.

Concentration

Solvent

Volume

11651.8-K-ME

Dopamine

51-61-6

1000 µg/mL

methanol with 5%

1 mL

1M HCl

11648.9-K-ME

(±)-Epinephrine hydrochloride

329-63-5

1000 µg base/mL

methanol

1 mL

11653.10-K-ME

5-Hydroxyindole-3-acetic acid

54-16-0

1000 µg/mL

methanol

1 mL

(5-HIAA)

10983.10-10MG

5-Hydroxyindole-3-acetic-2,2-d2

56209-31-5

neat

neat

10 mg

acid (5-HIAA-d2)

11646.10-K-ME

(±)-Metanephrine hydrochloride

881-95-8

1000 µg base/mL

methanol

1 mL

12006.10-100-ME

(±)-Metanephrine-α,β,β-d3

1085333-94-3

100 µg base/mL

methanol

1 mL

hydrochloride

12007.20-100-ME

(±)-Metanephrine-d3 hydrochloride

1215507-88-2

100 µg base/mL

methanol

1 mL

(N-methyl-d3)

11650.9-K-ME

3-Methoxytyramine hydrochloride

1477-68-5

1000 µg base/mL

methanol

1 mL

(3-MT HCl)

12008.9-100-ME

3-Methoxytyramine-d4 hydrochloride

1216788-76-9

100 µg base/mL

methanol

1 mL

12008.9-10MG

3-Methoxytyramine-d4 hydrochloride

1216788-76-9

neat

neat

10 mg

10518.10-1G

Methyldopa sesquihydrate

555-30-6

neat

neat

1 g

(α-Methyl-L-DOPA )

11649.8-K-ME

(±)-Norepinephrine hydrochloride

55-27-6

1000 µg base/mL

methanol

1 mL

11647.9-K-ME

(±)-Normetanephrine hydrochloride

1011-74-1

1000 µg base/mL

methanol

1 mL

12009.8-100-ME

(±)-Normetanephrine-α,β,β-d3

1085333-97-6

100 µg base/mL

methanol

1 mL

hydrochloride

12012.10-25MG

Serotonin hydrochloride

153-98-0

neat

neat

25 mg

(5-Hydroxytryptamine, 5-HT)

10864.10-100-ME

Serotonin-13C2,15N hydrochloride

153-98-0 (unlabelled)

100 µg base/mL

methanol

1 mL

(ethylamine-13C2,15N)

10864.10-5MG

Serotonin-13C2,15N hydrochloride

153-98-0 (unlabelled)

neat

neat

5 mg

(ethylamine-13C2,15N)

12010.9-100MG

(±)-Vanillomandelic acid

2394-20-9

neat

neat

100 mg

(VMA, HMMA)

10982.9-100-ME

(±)-Vanillomandelic acid-d3

74495-70-8

100 µg/mL

methanol

1 mL

(VMA-d3, HMMA-d3)

10982.9-50MG

(±)-Vanillomandelic acid-d3

74495-70-8

neat

neat

50 mg

(VMA-d3, HMMA-d3)

www.chiron.no | E-mail: sales@chiron.no | Tel.: +47 73 87 44 90 | Fax.: +47 73 73 87 44 99 | BMF 85 p.3/4, 12_16

BMF 85 – Biogenic Amines

Catalogue No.

Description

Cas No.

Component part

Catecholamine Mix 1

3 Compounds at 1000 μg base/mL in methanol

11646.1

(±)-Metanephrine hydrochloride

[881-95-8]

11647.9

(±)-Normetanephrine hydrochloride

[1011-74-1]

11650.9

3-Methoxytyramine hydrochloride

[1477-68-5]

S-4904-K-ME

1 x 1 mL ampoule

S-4904-K-MEx5

5 x 1 mL ampoules

Catalogue No.

Description

Cas No.

Component part

Catecholamine Mix 2

6 Compounds at 1000 μg base/mL in methanol

11646.1

(±)-Metanephrine hydrochloride

[881-95-8]

11647.9

(±)-Normetanephrine hydrochloride

[1011-74-1]

11648.9

(±)-Epinephrine hydrochloride

[329-63-5]

11649.8

(±)-Norepinephrine hydrochloride

[55-27-6]

11650.9

3-Methoxytyramine hydrochloride

[1477-68-5]

11651.8

Dopamine

[51-61-6]

S-4905-K-ME

1 x 1 mL ampoule

S-4905-K-MEx5

5 x 1 mL ampoules

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